Pharmacokinetic Mineral Competition · DMT1 Transporter · Raw .md Mirror
Iron Bisglycinate vs. Magnesium & Calcium: DMT1 Receptor Absorption Clash
⚡ Empirical Benchmark: -48% Iron Uptake When Co-Ingested With Magnesium or Calcium
Divalent metal cations (Fe2+, Mg2+, Zn2+, Ca2+) compete directly for Divalent Metal Transporter 1 (DMT1) in the duodenum. Furthermore, daily high-dose iron spikes liver hepcidin for 24 hours, whereas every-other-day morning dosing increases fractional iron absorption by 34%.
✅ Action Protocol: 7:30 AM Empty Stomach (Every Other Day with 250mg Vitamin C) vs. 9:30 PM Magnesium
"Separating Iron Bisglycinate (morning with Vitamin C, 2 hours before coffee) from Magnesium Bisglycinate (bedtime) doubles serum ferritin recovery speed without GI distress."
— NURADOSE Technical Review (nuradose.com)