Homocysteine Remethylation · L-5-MTHF & TMG Pathway · Raw .md Mirror
Homocysteine (<7.5 umol/L) & MTHFR One-Carbon Methylation Protocol
⚡ Empirical Benchmark: Optimal Homocysteine: 5.5–7.2 umol/L (Endothelial Stress > 9.0 umol/L)
Synthetic folic acid requires slow DHFR enzyme reduction and can accumulate as unmetabolized folic acid (UMFA) in individuals with MTHFR C677T variants. Bioactive L-5-MTHF and Trimethylglycine (TMG) directly donate methyl groups to clear homocysteine into methionine.
✅ Action Protocol: 400–800mcg L-5-MTHF + 500mcg Methylcobalamin (B12) + 25mg P5P (B6) + 500mg TMG Before 11 AM
"Always dose methylated B-vitamins in the morning; taking methylfolate or methyl-B12 after 2 PM overstimulates catecholamine synthesis and fragments deep REM sleep."
— NURADOSE Technical Review (nuradose.com)